Data di Pubblicazione:
2013
Citazione:
Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? / D. Rigante, L. Castellazzi, A. Bosco, S. Esposito. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 12:10(2013 Aug), pp. 1016-1021. [10.1016/j.autrev.2013.04.003]
Abstract:
Henoch–Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch–Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15 years' medical literature concerning the relationship between infections, genetics, and Henoch–Schönlein purpura in pediatrics.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Child; Genetics; Henoch-Schönlein purpura; Infection
Elenco autori:
D. Rigante, L. Castellazzi, A. Bosco, S. Esposito
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