Impaired fluidity and oxidizability of HDL hydrophobic core and amphipathic surface in dyslipidemic men

Articolo
Data di Pubblicazione:
2013
Citazione:
Impaired fluidity and oxidizability of HDL hydrophobic core and amphipathic surface in dyslipidemic men / R. Cazzola, E. Cassani, M. Barichella, B.A. Cestaro. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 62:7(2013), pp. 986-991. [10.1016/j.metabol.2013.01.012]
Abstract:
Objective: To examine and compare the composition, fluidity and oxidizability of HDL hydrophobic core and amphipathic surface of two groups of adult males (25kg/m(2)Pyrenyl-cholesteryl ester and pyrenyl-phosphatidylcholine, respectively incorporated in HDL core or surface were used for measuring both 2,2'-azobis-2-methyl-propanimidamide-dihydrochloride-induced peroxidation kinetics and fluidities of these regions. In comparison with the controls, MD HDL showed: a) higher free cholesterol to phospholipid ratio in surface and triacylglycerols to cholesteryl ester ratio in the core, b) higher malondialdehyde levels and lower alpha-tocopherol and beta-carotene to neutral lipid ratios, c) a more rigid surface and more fluid core, d) dramatically decreased lag-time and increased propagation rate of peroxidation kinetic in the core, but only an increased propagation rate on the surface. Conclusion: These results suggest that better knowledge of the physical-chemical properties and oxidizability of HDL core and surface could contribute to better understanding of the mechanisms connecting HDL alteration to increased risk of CDV in MD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mixed dyslipidemia ; HDL function ; lipid peroxidation ; lipoprotein fluidity
Elenco autori:
Autori di Ateneo:
Link alla scheda completa:
https://air.unimi.it/handle/2434/222207

Aree Di Ricerca

Settori


Settore BIO/10 - Biochimica