Peripheral blood abnormalities and bone marrow infiltration in canine large B-cell lymphoma : is there a link?
Articolo
Data di Pubblicazione:
2015
Citazione:
Peripheral blood abnormalities and bone marrow infiltration in canine large B-cell lymphoma : is there a link? / V. Martini, E. Melzi, S. Comazzi, M.E. Gelain. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5810. - 13:2(2015 Jun), pp. 117-123. [10.1111/vco.12024]
Abstract:
Official guidelines do not consider bone marrow (BM) assessment mandatory in staging canine lymphoma unless blood cytopenias are present. The aim of this study was to find out if blood abnormalities can predict marrow involvement in canine large B-cell lymphoma. BM infiltration was assessed via flow cytometry. No difference was found between dogs without haematological abnormalities and dogs with at least one. However, the degree of infiltration was significantly higher in dogs with thrombocytopenia, leucocytosis or lymphocytosis and was negatively correlated to platelet count and positively to blood infiltration. Our results suggest that blood abnormalities are not always predictive of marrow involvement, even if thrombocytopenia, leucocytosis or lymphocytosis could suggest a higher infiltration. BM evaluation should therefore be included in routine staging in order not to miss infiltrated samples and to improve classification. However, its clinical relevance and prognostic value are still not defined and further studies are needed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
bone marrow; cytopenia; dog; flow cytometry; lymphoma; staging
Elenco autori:
V. Martini, E. Melzi, S. Comazzi, M.E. Gelain
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