Gender differences in clinicopathological features and survuval in surgically treated patints with renal cell carcinoma: an analysis of the multicenter CORONA database
Articolo
Data di Pubblicazione:
2013
Citazione:
Gender differences in clinicopathological features and survuval in surgically treated patints with renal cell carcinoma: an analysis of the multicenter CORONA database / M. May, A. Aziz, R. Zigeuner, T. Chromecki, L. Cindolo, L. Schips, O. De Cobelli, B. Rocco, C. De Nunzio, A. Tubaro, I. Coman, M. Truss, O. Dalpiaz, B. Hoschke, C. Gilfrich, B. Feciche, A. Stoltze, F. Fenske, H.M. Fritsche, R.S. Figenshau, K. Madison, M. Sanchez-Chapado, M.D. Martin, L. Salzano, G. Lotrechiano, S. Joniau, R. Waidelich, C. Stief, S. Brookman-May. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - 31:5(2013), pp. 1073-1080.
Abstract:
Purpose: To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery. Methods: A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30-106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS). Results: A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868-0.870, p = 0.628) and OS (0.775-0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS. Conclusions: This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Age groups; Gender; Histological subtypes; Nephrectomy; Prognosis; Renal cell carcinoma
Elenco autori:
M. May, A. Aziz, R. Zigeuner, T. Chromecki, L. Cindolo, L. Schips, O. De Cobelli, B. Rocco, C. De Nunzio, A. Tubaro, I. Coman, M. Truss, O. Dalpiaz, B. Hoschke, C. Gilfrich, B. Feciche, A. Stoltze, F. Fenske, H.M. Fritsche, R.S. Figenshau, K. Madison, M. Sanchez-Chapado, M.D. Martin, L. Salzano, G. Lotrechiano, S. Joniau, R. Waidelich, C. Stief, S. Brookman-May
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