Data di Pubblicazione:
2008
Citazione:
Sphingolipids in macroautophagy / G. Lavieu, F. Scarlatti, G. Sala, S. Carpentier, T. Levade, R. Ghidoni, J. Botti, P. Codogno - In: Autophagosome and Phagosome / [a cura di] V. Deretic. - Totowa : Humana Press, 2008. - ISBN 9781588298539. - pp. 159-173
Abstract:
Sphingolipids are constituents of biological membranes. Ceramide and sphingosine 1-phosphate (S1P) also act as second messengers and are part of a rheostat system, in which ceramide promotes cell death and growth arrest, and S1P induces proliferation and maintains cell survival. As macroautophagy is a lysosomal catabolic mechanism involved in determining the duration of the lifetime of cells, we raised the question of its regulation by sphingolipid messengers. Using chemical and genetic methods, we have shown by GFP-LC3 staining and analysis of the degradation of long-lived proteins that both ceramide and S1P stimulate autophagy
Tipologia IRIS:
03 - Contributo in volume
Elenco autori:
G. Lavieu, F. Scarlatti, G. Sala, S. Carpentier, T. Levade, R. Ghidoni, J. Botti, P. Codogno
Link alla scheda completa:
Titolo del libro:
Autophagosome and Phagosome