Data di Pubblicazione:
2012
Citazione:
Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation / M.S. Christodoulou, F. Zunino, V. Zuco, S. Borrelli, D. Comi, G. Fontana, M. Martinelli, J.B. Lorens, L. Evensen, M. Sironi, S. Pieraccini, L. Dalla Via, O.M. Gia, D. Passarella. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 7:12(2012), pp. 2134-2143. [10.1002/cmdc.201200322]
Abstract:
The introduction of a methylenthiol group at position7 of camptothecin was carried out in four steps. This preparation also yielded the corresponding disulfide, which behaves as a prodrug due to its reactivity with glutathione. Assessment of their antiproliferative activities, investigations of their mechanism of action, and molecular modeling analysis indicated that the 7-modified camptothecin derivatives described herein maintain the biological activity and drug-target interactions of the parent compound.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M.S. Christodoulou, F. Zunino, V. Zuco, S. Borrelli, D. Comi, G. Fontana, M. Martinelli, J.B. Lorens, L. Evensen, M. Sironi, S. Pieraccini, L. Dalla Via, O.M. Gia, D. Passarella
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