Data di Pubblicazione:
2012
Citazione:
Placental fatty acid transport in maternal obesity / I. Cetin, F. Parisi, C. Berti, C. Mandò, G. Desoye. - In: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE. - ISSN 2040-1744. - 3:6(2012), pp. 409-414.
Abstract:
Pregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal obesity is associated with a specific proinflammatory,
endocrine and metabolic phenotype that may lead to higher supply of nutrients to the feto-placental unit and to excessive fetal fat
accumulation. In particular, obesity may influence placental fatty acid (FA) transport in several ways, leading to increased diffusion driving
force across the placenta, and to altered placental development, size and exchange surface area. Animal models show that maternal obesity is
associated with increased expression of specific FA carriers and inflammatory signaling molecules in placental cotyledonary tissue, resulting in
enhanced lipid transfer across the placenta, dislipidemia, fat accumulation and possibly altered development in fetuses. Cell culture experiments
confirmed that inflammatory molecules, adipokines and FA, all significantly altered in obesity, are important regulators of placental lipid
exchange. Expression studies in placentas of obese–diabetic women found a significant increase in FA binding protein-4 expression and in
cellular triglyceride content, resulting in increased triglyceride cord blood concentrations. The expression and activity of carriers involved in
placental lipid transport are influenced by the endocrine, inflammatory and metabolic milieu of obesity, and further studies are needed to
elucidate the strong association between maternal obesity and fetal overgrowth.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
fatty acids ; maternal obesity ; placental transport ; pregnancy
Elenco autori:
I. Cetin, F. Parisi, C. Berti, C. Mandò, G. Desoye
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