Data di Pubblicazione:
2013
Citazione:
GOLD NANOCONJUGATES: PREPARATION, CHARACTERISATION AND BIOLOGICAL APPLICATIONS / S. Avvakumova ; tutor: F. Porta, G. Scari ; coordinatore: D. Robertò. DIPARTIMENTO DI SCIENZE BIOMEDICHE E CLINICHE "L. SACCO", 2013 Jan 11. 25. ciclo, Anno Accademico 2012. [10.13130/avvakumova-svetlana_phd2013-01-11].
Abstract:
This PhD thesis is dedicated to the preparation, characterisation and biological application of gold nanoconjugates. Gold nanoparticles are prepared by various modern preparation methods, and subsequently characterised by spectroscopic (UV-vis, ATR-FTIR, NMR), microscopic (TEM) techniques. The stability of the conjugates is evaluated both by using Zeta-potential studies and UV-vis. The nanoparticles are used in cellular uptake experiments using human glioblastoma cancer cells, and are found to possess a low cytotoxicity. The nanoparticles are found taken up by the cells and distributed in different cellular compartments.
Tipologia IRIS:
Tesi di dottorato
Keywords:
gold nanoparticles ; bioconjugation ; peptides ; Halo Tag ; nucleic acid components
Elenco autori:
S. Avvakumova
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