HIGHLY STEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS BY CONDENSATION OF THE TITANIUM ENOLATE OF A CHIRAL 2-PYRIDYLTHIOESTER WITH CHIRAL IMINES
Articolo
Data di Pubblicazione:
1995
Citazione:
HIGHLY STEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS BY CONDENSATION OF THE TITANIUM ENOLATE OF A CHIRAL 2-PYRIDYLTHIOESTER WITH CHIRAL IMINES / R. Annunziata, M. Benaglia, A. Chiovato, M. Cinquini, F. Cozzi. - In: TETRAHEDRON. - ISSN 0040-4020. - 51:36(1995), pp. 10025-10032.
Abstract:
The reaction of the titanium enolalc of a 2-pyridylthioesler derived from (R)-3-hydroxybutync acid with chiral imines affords 3,3′-anti-3,4-trans configurated β-lactams in a highly selective fashion. The methodology has been applied to the synthesis of a precursor of the carbapenem antibiotic 1β-methylthienamycin.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Annunziata, M. Benaglia, A. Chiovato, M. Cinquini, F. Cozzi
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