Data di Pubblicazione:
2012
Citazione:
Revaluating serum ferritin as a marker of body iron stores in the traceability era / S. Ferraro, R Mozzi, M. Panteghini. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 50:11(2012), pp. 1911-1916. [10.1515/cclm-2012-0129]
Abstract:
Serum ferritin is used for diagnosing iron-related disorders.
However, most studies validating this application were performed
before the introduction of the 2nd and 3rd WHO
International Standards (ISs) to harmonize assay results. We
revised the available literature to evaluate if consolidated
clinical applications of ferritin and recommended cut-offs
have been validated using ISs calibrated assays. All Medline
retrieved reviews and individual studies performed since ISs
availability were selected and analyzed according to predefi
ned criteria. Concerning ferritin and iron defi ciency (ID),
only one review, including studies published before 1988, met
established criteria. Results showed that ferritin can effectively
rule out ID anemia in patients with or without infl ammatory
disease at cut-offs of 70 and 40 μ g/L, respectively.
From two studies using ISs calibrated assays that met inclusion
criteria, no information emerged on which cut-off should
be employed to obtain similar sensitivity. Regarding iron
overload, even when the framework was restricted to hereditary
hemochromatosis, no synthesis of scientifi c evidence, if
any, about diagnostic accuracy of ferritin was available both
before and after ISs introduction. Available evidence of the
ferritin diagnostic effectiveness is limited to ID conditions.
Recommended cut-offs for this application are, however,
based on studies published from 1970 to the 1980s using nonharmonized
assays.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anemia; Diagnosis; Ferritin; Harmonization; Hemochromatosis; Iron
Elenco autori:
S. Ferraro, R. Mozzi, M. Panteghini
Link alla scheda completa: