Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation
Articolo
Data di Pubblicazione:
2011
Citazione:
Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation / F. Bossi, B. Frossi, O. Radillo, M. Cugno, A. Tedeschi, P. Riboldi, R. Asero, F. Tedesco, C. Pucillo. - In: ALLERGY. - ISSN 0105-4538. - 66:12(2011 Dec), pp. 1538-1545. [10.1111/j.1398-9995.2011.02704.x]
Abstract:
Chronic urticaria (CU) is one of the most common skin disorders whose pathogenic mechanisms are not fully clarified. Autoimmune aetiology can be ascribed to 45% of patients with CU, and basophil histamine release is positive in 40% of cases. Our aim was to use a novel approach to evaluate the serum permeabilizing effect to identify the mediators of endothelial cell (EC) leakage and to define the role of mast cells (MCs) in the process
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Young Adult ; Humans ; Aged ; Capillary Permeability ; Urticaria ; Endothelial Cells ; Receptors, IgE ; Serum ; Adult ; Histamine Release ; Chronic Disease ; Middle Aged ; Mast Cells ; Female ; Male
Elenco autori:
F. Bossi, B. Frossi, O. Radillo, M. Cugno, A. Tedeschi, P. Riboldi, R. Asero, F. Tedesco, C. Pucillo
Link alla scheda completa: