Transplacental Supply of Mannose and Inositol in Uncomplicated Pregnancies Using Stable Isotopes
Articolo
Data di Pubblicazione:
2012
Citazione:
Transplacental Supply of Mannose and Inositol in Uncomplicated Pregnancies Using Stable Isotopes / B.C. Staat, H.L. Galan, J.E. Harwood, G. Lee, A.M. Marconi, C.L. Paolini, A. Cheung, F.C. Battaglia. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 97:7(2012 Jul), pp. 2497-2502.
Abstract:
OBJECTIVE:
The aim of this study was to determine relative contributions of transplacental flux vs. fetal production for inositol and mannose in normal term pregnancies.
STUDY DESIGN:
Seven term uncomplicated pregnancies undergoing cesarean section were infused with (13)C- and (2)H-labeled isotopes of glucose, inositol, and mannose until a steady state was achieved. Maternal and fetal concentrations of labeled and unlabeled glucose, mannose, and inositol were measured using gas chromatography/mass spectroscopy. The fetomaternal molar percentage excess ratio was calculated for each glucose, mannose, and inositol.
RESULTS:
The fetomaternal molar percentage excess ratio of mannose in the fetal artery (F(artery)/M) was 0.99 [97.5% confidence interval (CI), 0.91-1.07] and in the fetal vein (F(vein)/M), 1.02 (97.5% CI, 0.95-1.10). Both were not significantly different from 1.0, consistent with transplacental supply. The fetomaternal ratios for glucose were similar to mannose (fetal artery, 0.95; 97.5% CI, 0.84-1.15; and fetal vein, 0.96; 97.5% CI, 0.85-1.07). The fetomaternal ratio for inositol was significantly less than 1.0 (fetal artery, 0.08; 97.5% CI, 0.05-0.12; fetal vein, 0.12; 97.5% CI, 0.06-0.18), indicating little transplacental flux and significant fetal production.
CONCLUSION:
In normal term pregnancies, fetal mannose and glucose concentrations are dependent upon maternal transplacental supply. Fetal inositol is not dependent upon transplacental supply.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
pregnancy; stable isotopes; mannose
Elenco autori:
B.C. Staat, H.L. Galan, J.E. Harwood, G. Lee, A.M. Marconi, C.L. Paolini, A. Cheung, F.C. Battaglia
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