Inhibitory action of acetylcholine, baclofen and GTP-gamma-S on calcium channels in adult rat sensory neurons
Articolo
Data di Pubblicazione:
1991
Citazione:
Inhibitory action of acetylcholine, baclofen and GTP-gamma-S on calcium channels in adult rat sensory neurons / A. Formenti, V. Sansone. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 131:2(1991), pp. 267-272.
Abstract:
High- and low-voltage activated calcium channel currents (HVA and LVA) were inhibited by acetylcholine (10-100-mu-M) and baclofen (10-mu-M) in adult rat sensory neurons. This modulatory effect was present on dihydropyridine (nifedipine 1-mu-M) and/or omega-conotoxin (3.2-mu-M, 2-5 h incubation) insensitive components and was insensitive to holding potentials (V(h) -50 to -90 mV). GTP-gamma-S (100-mu-M) prolonged calcium channel current activation in a time- and voltage-dependent manner. On the other hand, the current amplitude reduction induced by muscarinic and GABA(B) receptor activation, was not relieved by a 50-ms conditioning prepulse to +50 mV. This suggests the possibility of an alternative voltage-independent modulation mechanism.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
CA-channel; acetylcholine; baclofen; sensory neuron; patch-clamp
Elenco autori:
A. Formenti, V. Sansone
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