Inhibition of Neutrophil Elastase and Metalloprotease-9 of Human Adenocarcinoma Gastric Cells by Chamomile (Matricaria recutita L.) Infusion
Articolo
Data di Pubblicazione:
2012
Citazione:
Inhibition of Neutrophil Elastase and Metalloprotease-9 of Human Adenocarcinoma Gastric Cells by Chamomile (Matricaria recutita L.) Infusion / M. Bulgari, E. Sangiovanni, E. Colombo, O. Maschi, D. Caruso, E. Bosisio, M. Dell'Agli. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - 26:12(2012), pp. 1817-1822. [10.1002/ptr.4657]
Abstract:
This study investigated whether the antiinflammatory effect of chamomile infusion at gastric level could be
ascribed to the inhibition of metalloproteinase-9 and elastase. The infusions from capitula and sifted flowers (250–1500mg/mL) and individual flavonoids (10mM) were tested on phorbol 12-myristate 13-acetate-stimulated AGS cells and human neutrophil elastase. The results indicate that the antiinflammatory activity associated with chamomile infusions from both the capitula and sifted flowers is most likely due to the inhibition of neutrophil elastase and gastric metalloproteinase-9 activity and secretion; the inhibition occurring in a concentration dependent manner. The promoter activity was inhibited as well and the decrease of metalloproteinase-9 expression
was found to be associated with the inhibition of NF-kB driven transcription. The results further indicate
that the flavonoid-7-glycosides, major constituents of chamomile flowers, may be responsible for the antiinflammatory action of the chamomile infusion observed here
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chamomile ; Matricaria recutita ; metalloprotease ; elastase ; gastritis ; flavonoids
Elenco autori:
M. Bulgari, E. Sangiovanni, E. Colombo, O. Maschi, D. Caruso, E. Bosisio, M. Dell'Agli
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