Data di Pubblicazione:
2012
Citazione:
CSF microRNAs in HIV-Associated Neurological Disorders / M. Pacifici, S. Delbue, P. Ferrante, D. Jeansonne, F. Kadri, S. Nelson, F. Peruzzi. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 18:Suppl 1(2012 May), pp. 81-82. (Intervento presentato al 11. convegno International Symposium on Neurovirology tenutosi a New York nel 2012) [10.1007/s13365-011-0059-9].
Abstract:
Since HIV-1 Tat has been associated with neurocognitive dysfunction, we investigated 60 HIV-1 subtype B-infected individuals who were characterized for neurocognitive functioning and had paired CSF and blood plasma samples available. To avoid issues with repeated sampling, we generated population-based HIV-1 tat sequences from each compartment and evaluated these data using a battery of phylogenetic, statistical, and machine learning tools. These analyses identified position HXB2 5905 within the cysteine-rich domain of tat as a signature of CSFderived HIV-1, and a higher number of mixed bases in CSF, as measure of diversity, was associated with HIV-associated neurocognitive disorder. Since identified mutations were synonymous, we evaluated the predicted secondary RNA structures, which showed that this mutation altered secondary structure. As a measure of divergence, the genetic distance between the blood and CSF-derived tat was inversely correlated with current and nadir CD4 + T cell counts. These data suggest that specific HIV-1 features of tat influence neurotropism and neurocognitive impairment.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Pacifici, S. Delbue, P. Ferrante, D. Jeansonne, F. Kadri, S. Nelson, F. Peruzzi
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