Data di Pubblicazione:
2012
Citazione:
In vitro and in vivo pharmacokinetic/pharmacodynamic activity of clofoctol / F. Scaglione, S. Dugnani, V. Lucini, M. Pannacci, L. Paraboni. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 24:4(2012), pp. 201-206.
Abstract:
The aim of the study was to examine the in vitro susceptibility of clinical isolates of respiratory pathogens to clofoctol compared with amoxicillin and erythromycin, and to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationships of clofoctol using a murine pneumonia infection model. Strains clinically isolated from patients between 2005 and 2009 were used to examine susceptibility: penicillin-susceptible Streptococcus pneumoniae, penicillin-resistant S. pneumoniae, Streptococcus pyogenes, methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus, and Haemophilus influenzae. The in vitro activity of clofoctol against clinical isolates has essentially remained unchanged over recent years. The MIC50 and MIC90 of clofoctol against penicillin-resistant S. pneumoniae are lower than that of amoxicillin and erythromycin. The area under curve/minimum inhibitory concentration (AUC/MIC) ratio is the PK/PD parameter that best correlates with in vivo clofoctol efficacy; the value of AUC/MIC required to achieve the maximum effect in this study was 75.5.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clofoctol; MIC; Pharmacodynamics; Pharmacokinetics
Elenco autori:
F. Scaglione, S. Dugnani, V. Lucini, M. Pannacci, L. Paraboni
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