Data di Pubblicazione:
2000
Citazione:
+4 or trisomy 4 / A. Beghini. - In: ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY. - ISSN 1768-3262. - 4:3(2000 Jul), pp. 129-130. [10.4267/2042/37648]
Abstract:
Clinics and pathology
Disease
Acute non lymphocytic leukaemia (ANLL)
Epidemiology
+4 as the sole anomaly is a rare chromosomal abnormality associated with a specific subtype of primary ANLL and secondary (treatment related) ANLL with myelomonocytic morphology; it has been
found with the same frequence in the M1-M2 and M4 French-American-British (FAB) phenotypes.
Association of +4 with double minute chromosomes has been described in ten cases; five with AML-M2,
two with AML-M4, one with refractory anemia with excess of blasts in transformation (RAEB-T), one with
chronic myelomonocytic leukemia (CMMoL) and one with unclassified preleukemia.
The coincidence of +4 with t(8;21) or its variant t(6;21;8), observed in at least two cases of ANLL (M1 and M2), is therefore recurrent.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Beghini
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