Data di Pubblicazione:
2002
Citazione:
Human genome dispersal and evolution of 4q35 duplications and interspersed LSau
repeats / L. Ballarati, I. Piccini, L. Carbone, N. Archidiacono, A. Rollier, A. Marozzi, R. Meneveri, E. Ginelli. - In: GENE. - ISSN 0378-1119. - 296:1-2(2002 Aug 21), pp. 21-27.
Abstract:
We have investigated the evolutionary history of the 4q35 paralogous region, and
of a sub-family of interspersed LSau repeats. In HSA, 4q35 duplications were
localized at 1q12, 3p12.3, 4q35, 10q26, 20cen, whereas duplicons and
interspersed LSau repeats simultaneously labeled the p arm of acrocentric
chromosomes. A multi-site localization of 4q35-like sequences was also observed
in PTR, GGO, PPY, HLA (Hominoidea) and PAN (Old World monkey), thus indicating
that duplications of this region have occurred extensively in the two clades,
which diverged at least 25 million years ago. In HSA, PTR and PAN, 4q35-derived
duplicons co-localized with rDNA, whereas in GGO and PPY this association was
partially lacking. In PAN, the single- and multi-site distribution of rDNA and
paralogous sequences, respectively, indicates a different timing of sequence
dispersal. The sub-family of interspersed LSau repeats showed a lesser dispersal
than 4q35 duplications both in man and great apes. This finding suggests that
duplications and repeated sequences have undergone different
expansion/contraction events during evolution. The mechanisms underlying the
dispersal of paralogous regions may be further derived through studies comparing
the detailed structural organization of these genomic regions in man and
primates.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Ballarati, I. Piccini, L. Carbone, N. Archidiacono, A. Rollier, A. Marozzi, R. Meneveri, E. Ginelli
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