Data di Pubblicazione:
2003
Citazione:
Gene expression analysis in interstitial lung edema induced by saline infusion / M. Sabbadini, D. Barisani, E. Conforti, A. Marozzi, E. Ginelli, G. Miserocchi, R. Meneveri. - In: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE. - ISSN 0925-4439. - 1638:2(2003 Jul 14), pp. 149-156.
Abstract:
To investigate the molecular events taking place during the development of
hydraulic interstitial edema, we analyzed by microarray and conventional
molecular techniques the variation of gene expression in lung from rabbits
treated with slow-rate saline infusions. This analysis indicates that even a
condition characterized by a small increase in extravascular water can have a
significant influence on the inflammatory milieu. In this regard, cytokines, in
particular TNFalpha, can be considered early mediators capable of inducing
secondary effects on the injured tissue. Moreover, two MT1 genes were strongly
up-regulated, data consistent with their role as protective molecules.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Sabbadini, D. Barisani, E. Conforti, A. Marozzi, E. Ginelli, G. Miserocchi, R. Meneveri
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