Data di Pubblicazione:
1995
Citazione:
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation / T. Viganõ, A. Hernandez, A. Corsini, A. Granata, P. Belloni, R. Fumagalli, R. Paoletti, G. Folco. - In: EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION. - ISSN 0922-4106. - 291:2(1995 Oct 15), pp. 201-203.
Abstract:
The role of mevalonate and geranylgeraniol in the control of cellular proliferation of cultured human bronchial myocytes was examined by investigating the effect of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in mevalonate synthesis. Simvastatin inhibited the rate of growth of human bronchial smooth muscle cells in a concentration-dependent manner, with an IC50 value of 0.97 +/- 0.1 microM. Mevalonate (100 microM), as well as geranylgeraniol (5 microM), at their highest non-toxic concentrations, restored cell proliferation to control levels.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cell proliferation; Geranylgeraniol; Human bronchial myocyte; Mevalonate; Simvastatin
Elenco autori:
T. Viganõ, A. Hernandez, A. Corsini, A. Granata, P. Belloni, R. Fumagalli, R. Paoletti, G. Folco
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