Data di Pubblicazione:
1988
Citazione:
Effect of derivatives of trapidil on the expression of LDL receptors / J. Beitz, A. Corsini, A. Granata, R. Fumagalli, H.J. Mest, R. Paoletti. - In: BIOMEDICA BIOCHIMICA ACTA. - ISSN 0232-766X. - 47:10-11(1988), pp. S153-S156.
Abstract:
The influence of trapidil and some of its derivatives (AR 12456, AR 12463, AR 12465) on the LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2) was investigated. AR 12456 enhanced the uptake and degradation of 125 I-LDL in HEP G2, but inhibited this pathway in HSF. When this drug was preincubated with HEP G2 cells, and then the incubation medium was transferred to HSF, a stimulation of specific LDL pathway occurred also in this cell line. Trapidil, AR 12463 and AR 12465 were inactive under the same experimental conditions. These findings suggest that a metabolite of AR 12456 might be responsible for the enhanced expression of LDL receptors in human cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Liver Neoplasms ; Skin ; Pyrimidines ; Receptors, LDL ; Cells, Cultured ; Carcinoma, Hepatocellular ; Kinetics ; Humans ; Trapidil ; Lipoproteins, LDL ; Antihypertensive Agents ; Cell Line
Elenco autori:
J. Beitz, A. Corsini, A. Granata, R. Fumagalli, H.J. Mest, R. Paoletti
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