Data di Pubblicazione:
1992
Citazione:
Effects of beta blocking agent iontophoresis by modulated sinusoidal current / G.R. Ghighineishvili, V. Balsamo, P.G. Sirtori, A. Miani, M. Lanfranchi, L. Dagnoni, F. Mauro. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 140:6(1992 Jun), pp. 539-543.
Abstract:
The action of the transcutaneous application of propranolol using modulated sinusoidal current iontophoresis was studied. When this way of administration is used, the drug, while maintaining its negative chronotropic effect, loses the negative inotropic one. Investigations were performed on 58 men aged 32 to 62 who underwent an aortocoronary bypass for myocardial ischemia. Thirty-four patients had already had myocardial infarction. The drug reduced the heart rate and increased cardiac contractility. Moreover, the study showed that only the levogyral isomer of propranolol (the only active one) passes through the skin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adrenergic ; beta-Antagonists/administration & dosage ; Adult Coronary Artery Bypass ; Coronary Disease/surgery ; Heart Rate/drug effects ; Humans ; Iontophoresis ; Male Middle Aged ; Myocardial Contraction/drug effects ; Postoperative Care ; Propranolol/administration & dosage ; Propranolol/pharmacology
Elenco autori:
G.R. Ghighineishvili, V. Balsamo, P.G. Sirtori, A. Miani, M. Lanfranchi, L. Dagnoni, F. Mauro
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