Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue
Articolo
Data di Pubblicazione:
2010
Citazione:
Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue / F. Fiori, A. Farini, A. Manescu, C. Villa, Y. Torrente. - In: NANOTECHNOLOGY. - ISSN 0957-4484. - 3:(2010), pp. 81-84.
Abstract:
In the perspective of clinical translation of stem cell research, the possibility to detect donor cells after transplantation and to track their fate is fundamental for a better understanding of their role in the regeneration of damaged tissues. In this article we summarize the results of ex-vivo and in-vivo X-ray computed microtomography experiments for 3D visualization of stem cells labeled with iron oxide nanoparticles and transplanted via intra-arterial infusion. We show that X-ray computed microtomography offers the possibility to detect with high definition and resolution human cells after transplantation, and opens new possibilities for experimental stem cell research.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Muscular dystrophy; Nanoparticle labeling; Stem cells; X-ray computed microtomography
Elenco autori:
F. Fiori, A. Farini, A. Manescu, C. Villa, Y. Torrente
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