Bronchoconstriction by histamine and bradykinin in guinea pigs: relationship to thromboxane A2 generation and the effect of aspirin
Articolo
Data di Pubblicazione:
1980
Citazione:
Bronchoconstriction by histamine and bradykinin in guinea pigs: relationship to thromboxane A2 generation and the effect of aspirin / G. Rossoni, C. Omini, T. Vigano, V. Mandelli, G.C. Folco, F. Berti. - In: PROSTAGLANDINS. - ISSN 0090-6980. - 20:3(1980), pp. 547-557. [10.1016/0090-6980(80)90042-8]
Abstract:
Histamine 2.5, 5, 10 or 20 microgram/kg i.v. induce a pronounced bronchospasm in guinea-pigs, accompanied by a dose-related increase of TXA2 in arterial blood, as revealed by contraction of rabbit isolated aorta and by radioimmunoassay. Aspirin 10 mg/kg prevented formation of TXA2-like material without significantly modifying the severity of the bronchospasm. Bradykinin 0.5, 1 or 2 microgram/kg i.v. acted similarly, except that pretreatment with aspirin blocked both the increased airway resistance and release of TXA2. Aspirin also blocked the increase in blood pressure and heart rate caused by histamine or bradykinin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bronchial Spasm ; Blood Pressure; Bradykinin ; Thromboxane A2 ; Histamine ; Aspirin ; Acetylcholine ; Guinea Pig
Elenco autori:
G. Rossoni, C. Omini, T. Vigano, V. Mandelli, G.C. Folco, F. Berti
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