Interference of the new antiinflammatory compound flunoxaprofen with eicosanoid formation in various biological systems
Articolo
Data di Pubblicazione:
1987
Citazione:
Interference of the new antiinflammatory compound flunoxaprofen with eicosanoid formation in various biological systems / F. Berti, G. Galli, C. Omini, G. Rossoni, G. Brunelli, L. Daffonchio, T. Viganò, F. Magni, M.T. Crivellari, A. Forgione. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 37:1(1987), pp. 27-32.
Abstract:
S-(+)-2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazolacetic acid (flunoxaprofen, Priaxim is a new antiinflammatory compound, which in various biological systems interferes with the generation and release of arachidonic acid metabolites of the cyclo-oxygenase pathways without affecting the formation of 5- and 12-lipoxygenase products. Flunoxaprofen reduces the concentration of thromboxane (TX)B2 (ED50 = 35.4 mg/kg p.o.) and prostaglandin (PG)E2-like activity (ED50 = 39.9 mg/kg p.o.) in the inflammatory exudate of rats 8 h after implantation of sponges soaked with carrageenan, whereas the concentration of leukotriene (LT)B4 remains in the range of that of the untreated animals (3.1 ng/ml). Flunoxaprofen inhibits cell infiltration in the exudate and this suggests that LTB4 does not initiate cell recruitment but may represent a mechanism for amplifying the inflammatory response. Using human platelets challenged with collagen, flunoxaprofen only at higher concentration (10(-4) mol/l) reduces TXB2 formation without altering generation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. This suggests a low capacity of flunoxaprofen of affecting platelet aggregation regulated by arachidonic acid metabolites. Flunoxaprofen prevents pulmonary changes due to secondary release of TXA2 in the guinea-pig. In fact this drug prevents changes due to immunological reaction and antagonizes bronchoconstriction due to exogenous administration of histamine and LTC4.(ABSTRACT TRUNCATED AT 250 WORDS)
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anti-Inflammatory Agents ; Eicosanoic Acids ; Lung ; flunoxaprofen
Elenco autori:
F. Berti, G. Galli, C. Omini, G. Rossoni, G. Brunelli, L. Daffonchio, T. Viganò, F. Magni, M.T. Crivellari, A. Forgione
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