Data di Pubblicazione:
1994
Citazione:
omega-Conotoxin GVIA binds to and blocks rat neuromuscular junction / G. Rossoni, F. Berti, L. La Maestra, F. Clementi. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 176:2(1994), pp. 185-188.
Abstract:
The effect of omega-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that 125I-omega-conotoxin binds to rat tibialis muscle end-plate; that omega-conotoxin blocks the neuromuscular transmission both in vivo, in the sciatic nerve-tibialis anterior muscle, and in vitro in the isolated phrenic nerve-diaphragm preparation; and does not affect muscle nicotinic receptors. We conclude that in rat neuromuscular junctions N-type calcium channels are important for neurotransmitter secretion.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Autoradiography; N-type calcium channel; Nicotinic receptor; Rat neuromuscular junction; α-Bungarotoxin; ω-Conotoxin
Elenco autori:
G. Rossoni, F. Berti, L. La Maestra, F. Clementi
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