Homocysteine, red cell, and plasma folate concentrations and birth weight in Italian women: results from a prospective study
Articolo
Data di Pubblicazione:
2011
Citazione:
Homocysteine, red cell, and plasma folate concentrations and birth weight in Italian women: results from a prospective study / F. Parazzini, F. Chiaffarino, E. Ricci, L. Improta, G. Monni. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - 24:3(2011 Mar), pp. 427-431. [10.3109/14767058.2010.501127]
Abstract:
Methods. aEuro integral A cohort of pregnant women was identified in 21 Italian obstetric centers. Women were eligible at 8th--10th week of gestation. All women were followed up to delivery in order to collect information on pregnancy outcome and birth weight (BW).
Results. aEuro integral Two hundred forty-four women were included in the analysis. In women not reporting current use of folate at study entry, the median homocysteine levels (mu mu mol/l) were 7.9, 8.1, and 8.5 at the 8th--10th, 16th, and 22nd week of gestation, respectively; the median red cells folate levels (nmol/dl) were 3.9, 6.1, and 7.0. The mean BW tended to be lower in the 2nd and 3rd tertile of homocysteine levels in comparison with the 1st tertile (p < 0.05 at the 8th--10th and 22nd week). The mean week of gestation at birth was higher in subjects in the 2nd and 3rd tertile of red cell folate at the 8th--10th and 16th week of gestation.
Conclusion. aEuro integral This study estimated homocysteine and plasma folate levels in Italian pregnant women and suggested that homocysteine level was associated with BW.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
birth weight; folate; gestational week; homocysteine; Pregnancy
Elenco autori:
F. Parazzini, F. Chiaffarino, E. Ricci, L. Improta, G. Monni
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