Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction
Articolo
Data di Pubblicazione:
2012
Citazione:
Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction / A. Pinelli, S. Trivulzio, S. Brenna, V. Rosato, L. Rivoltini, G. Rossoni. - In: JOURNAL OF CLINICAL & EXPERIMENTAL CARDIOLOGY. - ISSN 2155-9880. - 3:7(2012), pp. 202-204. [10.4172/2155-9880.1000202]
Abstract:
Background: Coronary artery disease (CAD) evolving to acute myocardial infarction (AMI) is due to the
thrombotic occlusion of coronary vessels in the presence of destabilized atheroma, rich in inflammatory cells
secreting proteolytic enzymes that induce the development of thrombosis. The aim of this study was to analyse the
plasma of AMI patients for the detection of proteases or factors that may cause fast coagulation.
Methods: The patients were analysed for the presence in plasma of cardiac troponin T (c-TnT) or proteases
as neutrophil gelatinase-associated lipocalin (NGAL) using ELISA method and matrix metalloproteinase-9 (MMP-9)
utilising flow cytometry technique and interleukin-8 (IL-8) using flow cytometry methodology.
Results: The presence of AMI was demonstrated by high levels of c-TnT; in comparison with controls the AMI
patients displayed a significant increase in the values of MMP-9 and low levels of antithrombin III: these markers
were negatively correlated: MMP-9 appeared to cause the coagulation activity documented by the consumption of
antithrombin III. The same patients also showed high levels of NGAL, which is known to modulate MMP-9 activity
and to be involved in coagulation process: patients also exhibited an increased amount of IL-8 which appears to be
associated with high levels of NGAL: this cytokine seems to affect the values of NGAL which is linked to coagulation
process.
Conclusion: The high levels of MMP-9, NGAL and IL-8 in AMI patients seemed to be interrelated and connected
with the process leading to rapid coagulation. These markers may be measured in absence of AMI, particularly in
CAD patients, as their detection may reveal a risk of sudden coronary coagulation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acute myocardial infarction; coronary artery diseases; unstable atherosclerotic plaque; matrix metalloproteinase-9; neutrophil gelatinase-associated lipocalin; interleukin-8
Elenco autori:
A. Pinelli, S. Trivulzio, S. Brenna, V. Rosato, L. Rivoltini, G. Rossoni
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