Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis
Articolo
Data di Pubblicazione:
2005
Citazione:
Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis / W. Kruis, A. Dignass, E. Steinhagen Thiessen, J. Morgenstern, J. Mossner, S. Schreiber, M. Vecchi, A. Malesci, M. Reinshagen, R. Lofberg. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 11:44(2005 Nov 28), pp. 7001-7006. [10.3748/WJG.v11.i44.7001]
Abstract:
Aim: To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy. Methods: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI 6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk). Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn®, Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life (IBDQ), and laboratory tests. Results: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01) at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia. Conclusion: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Steroid; Refractory colitis; Ulcerative colitis; Granulocyte; Apheresis
Elenco autori:
W. Kruis, A. Dignass, E. Steinhagen Thiessen, J. Morgenstern, J. Mossner, S. Schreiber, M. Vecchi, A. Malesci, M. Reinshagen, R. Lofberg
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