Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery : a randomised trial
Articolo
Data di Pubblicazione:
2003
Citazione:
Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery : a randomised trial / S. Guaschino, E.D. Ricci, M. Franchi, G. Del Frate, C. Tibaldi, D. De Santo, F. Ghezzi, C. Benedetto, F. De Seta, F. Parazzini. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 110:2(2003 Oct 10), pp. 149-152. [10.1016/S0301-2115(03)00107-6]
Abstract:
Objectives: To evaluate the efficacy of clindamycin vaginal cream 2% once daily for 7 days in prolonging pregnancy. Study design: Randomised clinical trial of 112 women between 14 and 25 weeks of gestation with diagnosis of asymptomatic bacterial vaginosis were enrolled in a multicenter randomised trial and assigned to active or no treatment. A total of 55 women were assigned to clindamycin and 57 to no treatment. Main outcome measure: frequency of pre-term delivery. Results: The rates of pre-term delivery was 12.2% in the clindamycin group and 15.7% in the no treatment group (P=0.78). Birth weight was <2500 g in three and seven babies, respectively, in the two groups (P=0.32). Mean gestational ages at birth were 38.9 and 39.2 (P=0.52), respectively, in the clindamycin and no treatment groups. Conclusions: The results of this study suggest that treating asymptomatic bacterial vaginosis does neither markedly prolong pregnancy nor increase birthweight.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bacterial vaginosis; Clindamycin; Pre-term birth
Elenco autori:
S. Guaschino, E.D. Ricci, M. Franchi, G. Del Frate, C. Tibaldi, D. De Santo, F. Ghezzi, C. Benedetto, F. De Seta, F. Parazzini
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