Data di Pubblicazione:
2012
Citazione:
Cultivable and pyrosequenced fecal microflora in centenarians and young subjects / L. Drago, M. Toscano, V. Rodighiero, E. De Vecchi, G. Mogna. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 46:suppl. 1(2012 Oct), pp. S81-S84. ((Intervento presentato al convegno International Meeting on Probiotics, Prebiotics & New Foods tenutosi a Roma nel 2011.
Abstract:
GOAL: : The aim of this study was to characterize the composition of the
intestinal microbiota in healthy centenarians in comparison with younger adults,
considering both quantitative and qualitative aspects of gut community structure.
BACKGROUND: : The gut microbiota plays an essential role in human health. Toward
seniority, its balance is affected by deep physiological changes. Long-lived
people (age >90 y) have unusual features that differ from the younger elderly, so
they should be considered separately when analyzing age-related features.
However, they have been included in few studies and they have usually been
grouped together with the younger elderly.
STUDY: : The gut microbiota of 14 centenarians and 10 younger adults was
analyzed. Cultivable bacteria belonging to the following groups were enumerated:
enterobacteriaceae, Enterococcus, Staphylococcus, Lactobacillus, Bifidobacterium,
Clostridium, Bacteroides, and yeast. Lactobacilli and Bifidobacteria were further
characterized at the species level by pyrosequencing.
RESULTS: : In centenarians, we observed a reduction in the quantity of
enterobacteriaceae, bifidobacteria, and bacteroides and an increase in clostridia
sensu stricto (P<0.05). The number of Lactobacillus and Bifidobacterium species
isolated in centenarians and younger adults was similar. The composition of the
Lactobacillus subpopulation was quite different between the groups. The presence
of Bifidobacterium longum in the gut seems to be a particular feature in
centenarians. It is interesting to note that only 1 strain of B. longum was
isolated from each centenarian subject.
CONCLUSIONS: : The gut microbiota of centenarians has particular features that
differ from both younger adults and the younger elderly. Further studies would
help to understand whether the intestinal microbiota can influence life
expectancy and whether the administration of probiotic bacteria could help to
extend the longevity of human life.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
age; Bifidobacterium longum; centenarian; gut microbiota
Elenco autori:
L. Drago, M. Toscano, V. Rodighiero, E. De Vecchi, G. Mogna
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