Data di Pubblicazione:
1999
Citazione:
In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs / P. Minghetti, A. Casiraghi, L. Montanari, M.V. Monzani. - In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0928-0987. - 7:3(1999), pp. 231-236. [10.1016/S0928-0987(98)00030-X]
Abstract:
Clinical trials have shown the potential of benzoxazinones, a new class of organic nitrates, in cardiovascular therapy. In particular Sinitrodil possesses a coronary vascular selectivity greater than that of Nitroglycerin and Isosorbide dinitrate. The objective of this study was a preliminary evaluation of the ability of these new organic nitrate derivatives to reach therapeutical steady-state plasma concentrations following a transdermal administration. In vitro permeation studies through human stratum corneum and epidermis have been conducted on two members of this class: Sinitrodil (ITF 296) and ITF 1129. Comparative studies have also been carried out with Nitroglycerin, Isosorbide dinitrate and Nicorandil. Two different fixed concentrations were tested: 0.08% w/v solution and saturated solution. Sinitrodil could be considered a good candidate for transdermal administration on the basis of the in vitro permeation results and of the known therapeutical plasma concentration. Copyright (C) 1999 Published by Elsevier Science B.V.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Benzoxazinones; ITF 296; Sinitrodil; Skin permeation
Elenco autori:
P. Minghetti, A. Casiraghi, L. Montanari, M.V. Monzani
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