Quantitative muscle strength assessment in Duchenne muscular dystrophy: longitudinal study and correlation with functional measures
Articolo
Data di Pubblicazione:
2012
Citazione:
Quantitative muscle strength assessment in Duchenne muscular dystrophy: longitudinal study and correlation with functional measures / A. Lerario, S. Bonfiglio, M.P. Sormani, A. Tettamanti, S. Marktel, S. Napolitano, S. Previtali, M. Scarlato, M.G. Natali-Sora, E. Mercuri, N. Bresolin, T. Mongini, G. Comi, R. Gatti, F. Ciceri, G. Cossu, Y. Torrente. - In: BMC NEUROLOGY. - ISSN 1471-2377. - 12(2012), pp. 91.1-91.8.
Abstract:
Background: The aim of this study was to perform a longitudinal assessment using Quantitative Muscle Testing (QMT) in a cohort of ambulant boys affected by Duchenne muscular dystrophy (DMD) and to correlate the results of QMT with functional measures. This study is to date the most thorough long-term evaluation of QMT in a cohort of DMD patients correlated with other measures, such as the North Star Ambulatory Assessment (NSAA) or thee 6-min walk test (6MWT).
Methods: This is a single centre, prospective, non-randomised, study assessing QMT using the Kin Com (R) 125 machine in a study cohort of 28 ambulant DMD boys, aged 5 to 12 years. This cohort was assessed longitudinally over a 12 months period of time with 3 monthly assessments for QMT and with assessment of functional abilities, using the NSAA and the 6MWT at baseline and at 12 months only. QMT was also used in a control group of 13 healthy age-matched boys examined at baseline and at 12 months.
Results: There was an increase in QMT over 12 months in boys below the age of 7.5 years while in boys above the age of 7.5 years, QMT showed a significant decrease. All the average one-year changes were significantly different than those experienced by healthy controls. We also found a good correlation between quantitative tests and the other measures that was more obvious in the stronger children.
Conclusion: Our longitudinal data using QMT in a cohort of DMD patients suggest that this could be used as an additional tool to monitor changes, providing additional information on segmental strength.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
6-minute walk test; multicenter clinical-trials; molecular-genetics; leg strength; boys; epidemiology; children; torque; force; cinrg
Elenco autori:
A. Lerario, S. Bonfiglio, M.P. Sormani, A. Tettamanti, S. Marktel, S. Napolitano, S. Previtali, M. Scarlato, M.G. Natali-Sora, E. Mercuri, N. Bresolin, T. Mongini, G. Comi, R. Gatti, F. Ciceri, G. Cossu, Y. Torrente
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