Data di Pubblicazione:
2011
Citazione:
Effect of SOM230 on human and rat adrenal secretion in vitro / F.P. Giraldi, L. Pagliardini, M.F. Cassarino, F. Martucci, L. Castelli, E. Montanari, F. Cavagnini. - In: ENDOCRINE REVIEWS. - ISSN 0163-769X. - 32:3(2011), pp. P2-590.1-P2-590.1. ((Intervento presentato al 93. convegno Annual Meeting and Expo of the Endocrine Society tenutosi a Boston nel 2011.
Abstract:
SOM230, a recently developed somatostatin analogue, has been tested in patients with Cushing's disease with
promising results. Experimental evidence indicates a pituitary site of action but no data is yet available on any
direct adrenal effect on cortisol secretion. This aspect of the analogue's action appears worth investigating as
some patients with Cushing's syndrome have been known to experience adrenal insufficiency soon after
initiation of SOM230 treatment. Aim of the current study was to evaluate whether SOM230 modulates
corticosteroid secretion by normal adrenals in vitro. Methods: Primary cultures from 6 normal human adrenals
and 6 rat adrenals were incubated with 10-100 nM SOM230 with and without 10 nM ACTH.
Cortisol/corticosterone levels in medium were measured after 4 and 24 hours. Results: 10 nM SOM230
significantly increased corticosteroid levels after 24h incubation in both human (131.4 ± 1.55% of baseline,
p<0.05) and rat (138.1 ± 15.99%, p<0.05) adrenals; lesser effects were observed with 100 nM SOM (120.4 ±
9.33% p<0.05; 117.3 ± 15.49% N.S., for human and rat adrenals, respectively). The corticosteroid secretory
response to ACTH was unaffected by SOM230 co-incubation (at 24h human adrenals: cortisol 105.6 ± 7.16%
and 108.4 ± 6.99% of ACTH-stimulated wells for 10 nM and 100 nM SOM230, NS, respectively; rat
adrenals: corticosterone 98.3 ± 12.11 and 91.8 ± 12.55% of ACTH-stimulated wells for 10 nM and 100 nM
SOM230, respectively, NS.) Conclusions: SOM230 exerted an unexpected, moderate stimulatory effect on
adrenal corticosteroid secretion in vitro. This argues against an additional, direct adrenal inhibitory effect of
SOM230 in patients with Cushing's syndrome.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F.P. Giraldi, L. Pagliardini, M.F. Cassarino, F. Martucci, L. Castelli, E. Montanari, F. Cavagnini
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