Role of topical immunotherapy in the treatment of alopecia areata. Quality analysis of articles published between January 1977 and January 1988 about three treatments
Articolo
Data di Pubblicazione:
1990
Citazione:
Role of topical immunotherapy in the treatment of alopecia areata. Quality analysis of articles published between January 1977 and January 1988 about three treatments / L. Naldi, F. Parazzini, T. Cainelli, Reading Group. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 22:4(1990 Apr), pp. 654-656.
Abstract:
We conducted a survey of clinical trials to assess the scientific evidences presented for the practical use of dinitrochlorobenzene, squaric acid dibutylester, and diphencyprone in the treatment of alopecia areata. Twenty-six papers published between January 1977 and January 1988, in English, French, and Italian were selected. We used a standardized protocol of evaluation, which focused principally on the reporting of methods. Twelve papers were uncontrolled studies. Of the controlled studies, 11 had a self-controlled design, two studies involved the use of parallel concurrent controls, and seven were randomized trials. With regard to criteria for entry, follow-up schedules, and criteria for evaluation of response to treatment, the studies were scored generally poorly; therapeutic regimen, patients' characteristics, withdrawals, and description of side effects in these studies were rated more highly. In light of our results, further and better-designed studies are needed for acceptance of dinitrochlorobenzene, squaric acid dibutylester, and diphencyprone in current therapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alopecia Areata ; Dinitrochlorobenzene ; Administration, Cutaneous ; Immunotherapy ; Humans ; Cyclopropanes ; Cyclobutanes ; Meta-Analysis as Topic
Elenco autori:
L. Naldi, F. Parazzini, T. Cainelli, Reading Group
Link alla scheda completa: