Data di Pubblicazione:
2001
Citazione:
Oculomotor focal dystonia / G. Galardi, M. A. Volonté, L. Maderna, S. Amadio, R. Nemni, G. Comi. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 16:2(2001 Mar), pp. 366-370.
Abstract:
In vivo imaging of the dopamine transporter, a protein on the
terminals of dopaminergic projections from the substantia nigra
to the striatum, provides an excellent marker of the dopaminergic
system in patients with parkinsonism.1–8 Previous studies
have demonstrated that SPECT and [123I] b-CIT (2bcarboxymethoxy-
3b-(4-iodophenyl)tropane), an agent which
targets the dopamine transporter, is a sensitive marker of Parkinson’s
disease diagnosis and severity.9,10 The pattern of loss
of [123I] b-CIT uptake in Parkinson’s disease has been shown
to be region-specific within the basal ganglia (putamen > caudate)
consistent with postmortem evaluation of the dopaminergic
transporter in Parkinson’s disease.10,11 Furthermore, all
Parkinson’s disease patients have demonstrated significant bilateral
loss of [123I] b-CIT uptake even in patients early in
their disease with hemi-parkinsonism symptoms.12 In this report,
we present the results of dopamine transporter imaging in
a patient with hemi-parkinsonism with a history of repeated
hemorrhages due to a midbrain arteriovenous malformation
treated with radiation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Magnetic Resonance Imaging ; Ocular Motility Disorders ; Humans ; Evoked Potentials, Motor ; Electromyography ; Brain ; Dystonia ; Brain Ischemia ; Aged ; Oculomotor Muscles ; Blindness ; Female
Elenco autori:
G. Galardi, M. A. Volonté, L. Maderna, S. Amadio, R. Nemni, G. Comi
Link alla scheda completa: