Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population
Articolo
Data di Pubblicazione:
2011
Citazione:
Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population / L. Corrado, L. Bergamaschi, N. Barizzone, M.E. Fasano, F.R. Guerini, M. Salvetti, D. Galimberti, M.D. Benedetti, M. Leone, S. D'Alfonso. - In: JOURNAL OF MEDICAL GENETICS. - ISSN 0022-2593. - 48:3(2011), pp. 210-211.
Abstract:
BACKGROUND:
The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia.
OBJECTIVE:
To replicate this association in an independent population with a different genetic background.
METHODS:
The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland.
RESULTS:
It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52).
CONCLUSION:
These data provide further evidence of the association of MS disease with variation within CBLB.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
genome-wide association; susceptibility loci; epidemiology; Europe
Elenco autori:
L. Corrado, L. Bergamaschi, N. Barizzone, M.E. Fasano, F.R. Guerini, M. Salvetti, D. Galimberti, M.D. Benedetti, M. Leone, S. D'Alfonso
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