Data di Pubblicazione:
1994
Citazione:
Impact of ceftibuten on intestinal microflora: in vitro and in vivo studies / M.R. Gismondo, L. Drago, A. Lombardi, C. Fassina. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - 20:2(1994), pp. 55-59.
Abstract:
The present study examines the possible interference of ceftibuten on intestinal
microflora. In 60 germ-free mice, an intestinal microflora similar to the human
one was implanted. The mice were then treated with a single dose and twice the
therapeutic dose of ceftibuten. In another experiment, ten human volunteers were
given ceftibuten in doses equivalent to 400 mg/day for 7 days in order to
evaluate the ceftibuten faecal concentration, the possible interference on
microflora and the quantity of indacan (as a measure of the bacterial metabolism
in the gut) excreted in one day. The results obtained in vivo and in vitro have
shown that ceftibuten in therapeutic doses does not alter the equilibrium of
normal intestinal microflora.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M.R. Gismondo, L. Drago, A. Lombardi, C. Fassina
Link alla scheda completa: