Data di Pubblicazione:
1994
Citazione:
Escherichia coli : effect of fosfomycin trometamol on some urovirulence factors / M.R. Gismondo, L. Drago, C. Fassina, M.L. Garlaschi, M. Rosina, A. Lombardi. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 6:3(1994 Jun), pp. 167-172. [10.1080/1120009X.1994.11741147]
Abstract:
The aim of our study was to evaluate the interference of fosfomycin trometanol (F.T.), at subinhibitory concentrations (1/4 and 1/8 MICs), on some urovirulence factors of Escherichia coli (12 strains). We tested fimbriae production, adhesion to uroepithelial cells, hydrophobicity, motility and hemolysin production of E. coli grown in the presence or absence of F.T. The strains tested, grown in the presence of F.T. (1/8 MIC), were less capable of adhering to uroepithelial cells, had less hemagglutination and reduced motility. This behavior was enhanced at 1/4 MIC of F.T. The hemolysin production and hydrophobicity properties present in some of our tested strains also were significantly decreased when the E. coli were grown in the presence of sub-MIC concentrations of F.T. These results suggest that F.T. may be of clinical use as treatment for acute urinary tract infection and in pyelonephritis prophylaxis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
E. coli; fosfomycin trometamol; urovirulence factors
Elenco autori:
M.R. Gismondo, L. Drago, C. Fassina, M.L. Garlaschi, M. Rosina, A. Lombardi
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