Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of haemophilus influenzae in an animal model
Articolo
Data di Pubblicazione:
2000
Citazione:
Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of haemophilus influenzae in an animal model / L. Drago, M.C. Fassina, B. Mombelli, E. De Vecchi, A. Lombardi, M.R. Gismondo. - In: CHEMOTHERAPY. - ISSN 0009-3157. - 46:4(2000 Jul), pp. 275-281.
Abstract:
Thiamphenicol glycinate (TG) and its derivative thiamphenicol
glycinate N-acetylcysteinate (TGA) could be a valid therapeutic option in the
treatment of respiratory tract infections.
METHODS: Time-kill curves of TG and TGA and pulmonary clearance in Haemophilus
influenzae infected guinea pigs were compared with those of clarithromycin,
ceftriaxone and amoxicillin plus clavulanic acid.
RESULTS: The bacterial activities of the tested antibiotics were comparable. When
compared to the control group, lung bacterial counts were significantly lower for
the TGA group at 3 h vs. controls, while for the other treatments, significant
decreases were recorded after 6 h. All drugs showed a log count of <2.0 at 24 h
with respect to the control while at 48 h all groups demonstrated a log count of
<2.0.
CONCLUSIONS: Although the in vitro activity of the tested drugs evaluated by
time-kill curves seemed comparable, some pharmacokinetic and pharmacodynamic
characteristics of TGA contribute to improving the resolution of the infective
process.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amoxicillin plus clavulanic acid; Ceftriaxone; Clarithromycin; Guinea pigs; Haemophilus influenzae; Thiamphenicol
Elenco autori:
L. Drago, M.C. Fassina, B. Mombelli, E. De Vecchi, A. Lombardi, M.R. Gismondo
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