Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man
Articolo
Data di Pubblicazione:
1990
Citazione:
Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man / V. VENTAFRIDDA, M. BIANCHI, C. RIPAMONTI, P. SACERDOTE, F. DE CONNO, E. ZECCA, A.E. PANERAI. - In: PAIN. - ISSN 0304-3959. - 43:2(1990), pp. 155-162. [10.1016/0304-3959(90)91068-T]
Abstract:
In the rat we studied the effect of 3 tricyclic antidepressants: chlorimipramine, amitriptyline and nortriptyline, and the atypical antidepressant trazodone on pain thresholds when administered alone or together with morphine. Moreover, we evaluated the effect of the antidepressants on free morphine plasma concentrations both in the rat and in man. We observed that chlorimipramine and amitriptyline, two tricyclic antidepressants active on the serotoninergic system, induce analgesia and potentiate morphine analgesia in a dose-related fashion. The noradrenergic tricyclic nortriptyline and trazodone did not elicit analgesia and inconsistently affected morphine analgesia. In the rat, all drugs tested increased plasma concentrations of morphine with the exception of amitriptyline. In man, only chlorimipramine and amitriptyline increased the plasma concentration of the free opiate.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Analgesia; Antidepressants; Morphine
Elenco autori:
V. VENTAFRIDDA, M. BIANCHI, C. RIPAMONTI, P. SACERDOTE, F. DE CONNO, E. ZECCA, A.E. PANERAI
Link alla scheda completa: