A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population
Articolo
Data di Pubblicazione:
1992
Citazione:
A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population / F. Macciardi, J. L. Kennedy, L. Ruocco, L. Giuffra, P. Carrera, C. Marino, V. Rinaldi, E. Smeraldi, M. Ferrari. - In: BIOLOGICAL PSYCHIATRY. - ISSN 0006-3223. - 31:7(1992 Apr 01), pp. 720-8-728.
Abstract:
Some recent findings report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigrees segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Schizophrenia; Phenotype; Pedigree; Genetic Linkage; Humans; Genetic Markers; Schizophrenic Psychology; Chromosome Mapping; Italy; Chromosomes, Human, Pair 5
Elenco autori:
F. Macciardi, J. L. Kennedy, L. Ruocco, L. Giuffra, P. Carrera, C. Marino, V. Rinaldi, E. Smeraldi, M. Ferrari
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