No evidence of association or linkage disequilibrium between polymorphisms in the 5′ upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese population
Articolo
Data di Pubblicazione:
2004
Citazione:
No evidence of association or linkage disequilibrium between polymorphisms in the 5′ upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese population / A. Ambrosio, J. Kennedy, F. Macciardi, C. Barr, M. Soares, C. Oliveira, C. Pato. - In: AMERICAN JOURNAL OF MEDICAL GENETICS. PART B, NEUROPSYCHIATRIC GENETICS. - ISSN 1552-4841. - 125B:1(2004), pp. 20-24.
Abstract:
Alterations in dopaminergic system have been implicated in the
pathophysiology of this disease for many years, and this study was
performed to assess the possible involvement of the dopamine D4 receptor
(DRD4) gene polymorphisms either in the 5' upstream or in the coding
regions, in the etiology of schizophrenia. The approach included an
association study with 90 Portuguese trios by doing the analysis of the
individual alleles and the haplotypes. For the polymorphisms in the 5'
upstream region (-C616G and -C521T) and in the coding region (48 bp
repeat) of the DRD4 gene, negative results were obtained with both
haplotype relative risk (HRR) and transmission disequilibrium test
(TDT), as well as transmit. These data suggest that polymorphisms
(-C616G, -C521T, and 48 bp repeat) at the DRD4 gene do not have a minor
effect in the susceptibility to schizophrenia in our sample. (C) 2003
Wiley-Liss, Inc.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Association study; Candidate gene; Dopamine D4 receptor; Haplotypes; Linkage disequilibrium; Schizophrenia
Elenco autori:
A. Ambrosio, J. Kennedy, F. Macciardi, C. Barr, M. Soares, C. Oliveira, C. Pato
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