Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population
Articolo
Data di Pubblicazione:
2004
Citazione:
Family association study between DRD2 and DRD3 gene polymorphisms and
schizophrenia in a Portuguese population / A. Ambrosio, J. Kennedy, F. Macciardi, A. Macedo, J. Valente, A. Dourado, C. Oliveira, C. Pato. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 125:3(2004), pp. 185-191.
Abstract:
Schizophrenia is a highly heritable condition, as demonstrated in
family, twin and adoption studies. Candidate genes from the dopaminergic
system have long been hypothesized to be involved in the etiology of
this disorder. In the present study, we investigated the genetic
association between polymorphisms in the D2 and D3 dopamine receptor
(DRD2, DRD3) genes and schizophrenia. We examined 90 trios from
Portugal, and negative results were obtained from association studies
with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium
Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the
DRD2 nor the DRD3 gene polymorphisms investigated are associated with
schizophrenia in our sample. (C) 2004 Elsevier Ireland Ltd. All rights
reserved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Association study; Candidate genes; Haplotypes; Linkage disequilibrium; Schizophrenia
Elenco autori:
A. Ambrosio, J. Kennedy, F. Macciardi, A. Macedo, J. Valente, A. Dourado, C. Oliveira, C. Pato
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