Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dα and 5-HT1Dβ autoreceptor genes: Family-based association study
Articolo
Data di Pubblicazione:
2004
Citazione:
Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dα and 5-HT1Dβ autoreceptor genes: Family-based association study / A. Ambrosio, J. Kennedy, F. Macciardi, I. Coelho, M. Soares, C. Oliveira, C. Pato. - In: AMERICAN JOURNAL OF MEDICAL GENETICS. PART B, NEUROPSYCHIATRIC GENETICS. - ISSN 1552-4841. - 128B:1(2004), pp. 1-5. [10.1002/ajmg.b.30023]
Abstract:
Genetic factors play a major role in the etiology of schizophrenia and
disturbances of serotonergic pathways have been implicated in this
disorder. The aim of the present study was to examine genetic
association between schizophrenia and polymorphisms in the 5-HT1Dalpha
(TaqI) and 5-HT1DPbeta (T261G and G861C) autoreceptor genes in ninety
trios from Portugal. No association or linkage disequilibrium. was
obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta
autoreceptor genes with both haplotype relative risk (HRR) and
transmission disequilibrium test (TDT). Concerning 5-HT1Dbeta
autoreceptor gene, also negative results was obtained in the analysis of
the haplotypes with transmit. Thus, our data provide no support for the
hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta
(T261G and G861C) genes contributes to susceptibility to schizophrenia
in the Portuguese population. (C) 2004 Wiley-Liss, Inc.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Candidate genes; Haplotypes; Introduction; Linkage disequilibrium; Serotoninergic system
Elenco autori:
A. Ambrosio, J. Kennedy, F. Macciardi, I. Coelho, M. Soares, C. Oliveira, C. Pato
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