The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder : an evolutionary perspective
Articolo
Data di Pubblicazione:
2004
Citazione:
The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder : an evolutionary perspective / R. Levitan, M. Masellis, V. Basile, R. Lam, A. Kaplan, C. Davis, P. Muglia, B. Mackenzie, S. Tharmalingam, S. Kennedy, F. Macciardi, J. Kennedy. - In: BIOLOGICAL PSYCHIATRY. - ISSN 0006-3223. - 56:9(2004), pp. 665-669.
Abstract:
Background: We recently described a preliminary association between the
hypofunctional seven-repeat allele of the dopamine-4 receptor gene
(DRD4) and increased maximal lifetime body mass index in women with
seasonal affective disorder (SAD). in this study, we examined whether
binge eating behavior mediated this putative association.
Methods: The study sample consisted of 131 women with winter SAD who
reported increased intake of high-carbohydrate/high-fat foods during
depressive episodes. We compared rates of binge eating behavior in The
two genotypic groups defined by the presence or absence of the
seven-repeat allele of DRD4.
Results: Consistent with our working hypothesis, the proportion of binge
eaters was significantly greater in probands with the seven-repeat
allele (18 of 46, 39.1\%) than inprobands wilbout this allele (14 of 85,
16.5\%{[chi(2)(1)= 8.32, p =.004,- odds ratio = 3.25, 95\% confidence
interval 1.43, 7.41].
Conclusions: Pending replication in other samples, these results point
to a genetic factor that could help in the early identification and
treatment of women at higher risk for seasonal weight gain associated
with binge eating behavior. At a theoretic level, the current results
suggest a novel link between evolutionary models of seasonal weight gain
on The one band and the DRD4 gene on the other.}
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
binge eating; dopamine-4 receptor gene; genetics; positive selection; Seasonal affective disorder; weight gain
Elenco autori:
R. Levitan, M. Masellis, V. Basile, R. Lam, A. Kaplan, C. Davis, P. Muglia, B. Mackenzie, S. Tharmalingam, S. Kennedy, F. Macciardi, J. Kennedy
Link alla scheda completa: