Data di Pubblicazione:
2004
Citazione:
Support for EKN1 as the susceptibility locus for dyslexia on 15q21 / K. Wigg, J. Couto, Y. Feng, B. Anderson, T. Cate-Carter, F. Macciardi, R. Tannock, M. Lovett, T. Humphries, C. Barr. - In: MOLECULAR PSYCHIATRY. - ISSN 1359-4184. - 9:12(2004), pp. 1111-1121. [10.1038/sj.mp.4001543]
Abstract:
Dyslexia has been linked to a number of chromosomal regions including
15q. Recently a gene, EKN1, with unknown function in the linked region,
was identified via a translocation breakpoint. This gene was further
supported as a susceptibility locus by association studies in a Finnish
sample. We investigated the possibility of this locus as a
susceptibility gene contributing to dyslexia, analyzed as a categorical
trait, and analyzed key reading phenotypes as quantitative traits using
six polymorphisms including the two previously reported to be associated
with dyslexia. In our sample of 148 families identified through a
proband with reading difficulties, we found significant evidence for an
association to dyslexia analyzed as a categorical trait and found
evidence of association to the reading and related processes of
phonological awareness, word identification, decoding, rapid automatized
naming, language ability, and verbal short-term memory. However,
association was observed with different alleles and haplotypes than
those reported to be associated in a Finnish sample. These findings
provide support for EKN1 as a risk locus for dyslexia and as
contributing to reading component processes and reading-related
abilities. Based on these findings, further studies of this gene in
independent samples are now required to determine the relationship of
this gene to dyslexia.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chromosome 15q; Dyslexia; EKN1; Genetics; Reading disabilities
Elenco autori:
K. Wigg, J. Couto, Y. Feng, B. Anderson, T. Cate Carter, F. Macciardi, R. Tannock, M. Lovett, T. Humphries, C. Barr
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