A linkage study between the GABA(A beta 2) and GABA(A gamma 2) subunit genes and major psychoses
Articolo
Data di Pubblicazione:
2005
Citazione:
A linkage study between the GABA(A beta 2) and GABA(A gamma 2) subunit
genes and major psychoses / A. Ambrosio, J. Kennedy, F. Macciardi, N. King, M. Azevedo, C. Oliveira, C. Pato. - In: CNS SPECTRUMS. - ISSN 1092-8529. - 10:1(2005), pp. 57-61.
Abstract:
Background: Alterations of the gamma-aminobutyric acid (GABA) system
have been implicated in the pathophysiology of major psychoses.
Objective: Restriction fragment length polymorphisms associated with the
human gamma-aminobutyric acid type A (GABA(A)) beta(2) and GABA(A)
gamma(2) subunit genes on chromosome 5q32-q35 were tested to determine
whether they confer susceptibility to major psychoses.
Methods: Thirty-two schizophrenic families and 25 bipolar families were
tested for linkage.
Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER
showed no significant NPL scores for both genes in schizophrenia
(GABA(A) beta2: NPL narrow=-0.450; NPL broad=-0.808; GABA(A) gamma(2):
NPL narrow=0.177; NPL broad=-0.051) or bipotar disorder (GABA(A)
beta(2): NPL narrow=0.834; NPL broad=0.783; GABA(A) gamma(2): NPL
narrow=-0.159; NPL broad=0.070).
Conclusion: Linkage analysis does not support the hypothesis that
variants within the GABA(A) beta(2) and GABA(A) gamma(2) genes are
significantly linked to major psychoses in a Portuguese population.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Ambrosio, J. Kennedy, F. Macciardi, N. King, M. Azevedo, C. Oliveira, C. Pato
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