Data di Pubblicazione:
2010
Citazione:
Pilot Study on Schizophrenia in Sardinia / J. Ott, F. Macciardi, Y. Shen, M.G. Carta, A. Murru, R. Triunfo, R. Robledo, A. Rinaldi, L. Contu, M. Siniscalco. - In: HUMAN HEREDITY. - ISSN 0001-5652. - 70:2(2010), pp. 92-96. [10.1159/000313844]
Abstract:
Objective: Based on a small sample of cases with schizophrenia and
control individuals from an isolated population, a genome-wide
association study was undertaken to find variants conferring
susceptibility to this disease. Methods: Standard association tests were
employed, followed by newer multilocus association methods (genotype
patterns). Results: Individually, no variant produced a significant
result. However, the best two variants (rs1360382 on chromosome 9 and
rs1303 on chromosome 14) showed significantly different genotype pattern
distributions between patients and control individuals. The risk
genotype pattern AA-TT is highly predictive of schizophrenia, with
estimated sensitivity and specificity of 1 and 0.96, respectively.
Conclusions: These findings support the hypothesis that schizophrenia is
partly due to multiple genetic variants, each with a relatively small
effect. Copyright (C) 2010 S. Karger AG, Basel
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Genetic association; Genome-wide association study; Schizophrenia
Elenco autori:
J. Ott, F. Macciardi, Y. Shen, M.G. Carta, A. Murru, R. Triunfo, R. Robledo, A. Rinaldi, L. Contu, M. Siniscalco
Link alla scheda completa: