Pharmacokinetic fluvoxamine - Clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient
Articolo
Data di Pubblicazione:
1996
Citazione:
Pharmacokinetic fluvoxamine - Clomipramine interaction with favorable
therapeutic consequences in therapy-resistant depressive patient / P. Conus, C. Bondolfi, C. Eap, F. Macciardi, P. Baumann. - In: PHARMACOPSYCHIATRY. - ISSN 0176-3679. - 29:3(1996), pp. 108-110.
Abstract:
We describe the case of a depressive patient who was a rapid metabolizer
of CYP2D6 substrates and a heavy smoker, and who did not respond to
several courses of treament with antidepressants, as a result of
unusually low drug-plasma levels. During hospitalization, he did not
improve after treatment with clomipramine (150-225 mg/day during three
weeks), but showed a response within four days after addition of
fluvoxamine (100 mg/day). Plasma levels of clomipramine and
desmethylclomipramine changed from 58 ng/ml and 87 ng/ml to 223 ng/ml
and 49 ng/ml respectively one week after addition of fluvoxamine.
Present knowledge of the role of cytochrome P-450 isozymes, such as
CYP1A2, CYP2C19, CYP2D6, and CYP3A4, in the metabolism of psychotropic
drugs as well as therapeutic drug-plasma level monitoring may thus help
to determine individual treatment.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Conus, C. Bondolfi, C. Eap, F. Macciardi, P. Baumann
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